1lbj

About this Structure
1LBJ is a Single protein structure. Full experimental information is available from OCA.

Biological Function
Motilin is a gastrointestinal peptide hormone released by the M-Cells in the epithelium of the small intestine. Its primary function is to increase gastric motility, that is, movement of digestive matter through the gut. It does so by stimulating contractions of the smooth muscle surrounding the intestines. In fasting humans, motilin is responsible for initiating the migrating motor complex, a coordinated peristalsis that clears material from the intestine, depositing it in the colon. Motilin secretion seems to be triggered by a high pH in the duodenum in most mammals. Motilin has also been shown to stimulate the emptying of the gallbladder into the small intestine.

Pharmacology
The antibiotic erythromycin is a strong motilin agonist, causing accelerated gastric emptying in subjects treated with it. A derivative of erythromycin, mitemcinal, has the same agonist ability without the antibiotic qualities and is currently under clinical development.

Reference
NMR solution structure and dynamics of motilin in isotropic phospholipid bicellar solution., Andersson A, Maler L, J Biomol NMR. 2002 Oct;24(2):103-12. PMID:12495026

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